Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, 14th Edition continues its legacy as the leading authority on drug action and clinical pharmacology. This edition introduces five new chapters—including pharmacovigilance, the blood–brain barrier, cannabis, biological therapies, and the gastrointestinal microbiome—along with expanded content on pharmacogenomics and drug mechanisms. Featuring over 600 color illustrations, updated drug fact tables, 50 new mechanism figures, and contributions from 53 new experts, it provides a comprehensive and clinically relevant guide for understanding, prescribing, and applying therapeutic agents in modern medical practice.